Not without a hell of a lot of work and some serious programming knowhow.
Right. It's going to be a good deal of work and definitely require some programming knowledge, even for games of the same system. pogoshell is an example of how you could potentially do it. You could create a simple BIOS or OS type program that acts as a ROM manager. I'm not entirely sure on the details as I've never sat down to think it out. I'd imagine difficulty will also depend on the platform in question.