I actually have a similar project in mind from a while ago, if anyone's interested. It's a Hokuto no Ken (Fist of the North Star) DS game, where the majority of the game's text is stored as text in manga panels. It's all uncompressed, in separate files in the game's filesystem. I just need someone willing to help me put those together (and hopefully make it look like manga) once translated.
~DS
If you can provide the bitmap images, I can typeset 'em. Check out the scans of Liar Game on my website. (Sorry if it's inconsistent; I got better as I went along.)